Cilostazol (OPC 13013, OPC 21) is a potent, selective inhibitor of PDE3A with IC50 of 0.2 uM.
Cilostazol (OPC 13013, OPC 21) inhibits platelet aggregation and has considerable antithrombotic effects in vivo.
Cilostazol (OPC 13013, OPC 21) relaxes vascular smooth muscle and inhibits mitogenesis and migration of vascular smooth muscle cells.
Cilostazol (OPC 13013, OPC 21) also upregulates autophagy via SIRT1 activation, has preventive effects on various central nervous system (CNS) diseases.
