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Cilostazol

Chemical Structure : Cilostazol

CAS No.: 73963-72-1

Cilostazol (OPC 13013, OPC 21)

Catalog No.: PC-45282Not For Human Use, Lab Use Only.

Cilostazol (OPC 13013, OPC 21) is a potent, selective inhibitor of PDE3A with IC50 of 0.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cilostazol (OPC 13013, OPC 21) is a potent, selective inhibitor of PDE3A with IC50 of 0.2 uM.
Cilostazol (OPC 13013, OPC 21) inhibits platelet aggregation and has considerable antithrombotic effects in vivo.
Cilostazol (OPC 13013, OPC 21) relaxes vascular smooth muscle and inhibits mitogenesis and migration of vascular smooth muscle cells.
Cilostazol (OPC 13013, OPC 21) also upregulates autophagy via SIRT1 activation, has preventive effects on various central nervous system (CNS) diseases.

Physicochemical Properties

M.Wt 369.4607
Formula C20H27N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2(1H)-Quinolinone, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-

References

1. Schrör K, et al. Diabetes Obes Metab. 2002 Mar;4 Suppl 2:S14-9.

2. Lee HR, et al. PLoS One. 2015 Aug 5;10(8):e0134486.

3. Qi DS, et al. Brain Res. 2016 Dec 15;1653:67-74.

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