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Cisapride monohydrate

Chemical Structure : Cisapride monohydrate

CAS No.: 260779-88-2

Cisapride monohydrate (R51619 monohydrate, (±)-Cisaprid monohydrate)

Catalog No.: PC-28212Not For Human Use, Lab Use Only.

Cisapride monohydrate (R 51619) is a potent, selective and orally active 5-HT4 receptor agonist with EC50 of 140 nM, is also an hERG potassium channel blocker with IC50 of 9.4 nM, inhibits voltage-dependent K(+) (Kv) channels using freshly isolated smooth muscle cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cisapride monohydrate (R 51619) is a potent, selective and orally active 5-HT4 receptor agonist with EC50 of 140 nM, is also an hERG potassium channel blocker with IC50 of 9.4 nM, inhibits voltage-dependent K(+) (Kv) channels using freshly isolated smooth muscle cells.

Physicochemical Properties

M.Wt 483.97
Formula C23H31ClFN3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

rel-4-Amino-5-chloro-N-((3R,4S)-1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide monohydrate

References

1. Kim HW, et al. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1423-8.

2. Walker BD, et al. Br J Pharmacol. 1999 Sep;128(2):444-50.

3. Ueki S, et al. J Pharmacol Exp Ther. 1993 Jan;264(1):152-7.

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