Catalog No.: PC-24203Not For Human Use, Lab Use Only.
Citral dimethyl acetal (CDA) is a specific inhibitor of γ-tubulin, specifically inhibits the nuclear activity of γ-tubulin without affecting microtubules dynamics, increases E2F activity without affecting microtubules.
Citral dimethyl acetal (CDA) is a specific inhibitor of γ-tubulin, specifically inhibits the nuclear activity of γ-tubulin without affecting microtubules dynamics, increases E2F activity without affecting microtubules. Citral dimethyl acetal prevents GTP binding to γ-tubulin. Citral dimethyl acetal affects E2F activity without interfering with astral microtubule outgrowth and mitotic progression. The cytotoxic effect of CDA treatment depends on the functionality of the RB1 signal transduction pathway. Citral dimethyl acetal inhibits in vivo growth of xenograft tumors carrying defects in the RB1 signaling pathway.
Physicochemical Properties
M.Wt
198.31
Formula
C12H22O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3,7-Dimethylocta-2,6-dienal dimethyl acetal
References
1. Lindström L, et al. Mol Cancer Res. 2015 Jul;13(7):1073-82.
