Citronellol is an orally active inducer of apoptosis and RIPK1 agonist. Citronellol prevents oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol reduces the levels of LC-3 and p62 to regulate the autophagy pathway, inhibits oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.
Physicochemical Properties
M.Wt
156.27
Formula
C10H20O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3,7-Dimethyloct-6-en-1-ol
References
1. Gong Q, et al. Cell Commun Signal. 2024 Sep 2;22(1):427.
2. Munir S, et al. Biomedicines. 2023 Oct 18;11(10):2820.
3. Shao J, et al. Neurotox Res. 2022 Dec;40(6):2221-2237
