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Cl-OCH3

Chemical Structure : Cl-OCH3

CAS No.: 2279970-72-6

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Cl-OCH3 (NR4A1 inhibitor Cl-OCH3)

Catalog No.: PC-38223Not For Human Use, Lab Use Only.

Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively.
    Cl-OCH3 decreased expression of PD-L1 mRNA, promoter-dependent luciferase activity, and protein. In in vivo studies using a syngeneic mouse model bearing orthotopically injected 4T1 cells.
    Cl-OCH3 decreased tumor growth and weight and inhibited lung metastasis.
    Cl-OCH3 also decreased expression of CD3+/CD4+/CD25+/FoxP3+ regulatory T cells and increased the Teff/Treg ratio.

    Physicochemical Properties

    M.Wt 402.878
    Formula C24H19ClN2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,1-bis(3'-indolyl)-1-(3-chloro-4-hydroxy-5-methoxyphenyl)methane

    References

    1. Keshav Karki, et al. Cancer Res. 2020 Mar 1;80(5):1011-1023.

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