ClC-1 inhibitor Compound A-3

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Chemical Structure : ClC-1 inhibitor Compound A-3

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Catalog No.: PC-23489Not For Human Use, Lab Use Only.

ClC-1 inhibitor Compound A-3 is a specific inhibitor of skeletal muscle-specific chloride ion (Cl-) channel ClC-1 with IC50 of 2.3 uM for reduction in the Cl- driven membrane conductance (Gm).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ClC-1 inhibitor Compound A-3 is a specific inhibitor of skeletal muscle-specific chloride ion (Cl-) channel ClC-1 with IC50 of 2.3 uM for reduction in the Cl- driven membrane conductance (Gm).
ClC-1 inhibitor Compound A-3 markedly accelerates recovery of both single contraction (twitch) and, important physiologically, sustained (tetanic) contractions in a rat model mimicking neuromuscular blocking agent-induced muscle block used during surgery.

Physicochemical Properties

M.Wt	323.13
Formula	C12H13BrF2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-bromo-2-(1,1-difluoropropyl)phenoxy)propanoic acid

References

1. Example 2 of patent WO2020/254559

2. Skals M, et al. Nat Commun. 2024 Oct 28;15(1):9289.

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