Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Claficapavir
Catalog No.: PC-73411Not For Human Use, Lab Use Only.
Claficapavir (A1752) is a specific small molecule inhibitor of HIV-1 nucleocapsid protein (Kd=20 nM), shows a strong antiviral efficacy with IC50 of 1 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Claficapavir (A1752) is a specific small molecule inhibitor of HIV-1 nucleocapsid protein (Kd=20 nM), shows a strong antiviral efficacy with IC50 of 1 uM.
A1752 binds directly to HIV-1 nucleocapsid protein (NC), specificly inhibits the chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization.
A1752 also disrupts the proper Gag processing.
A1752 generates noninfectious viral particles with defects in uncoating and reverse transcription in the infected cells.
| M.Wt | 393.856 | |
| Formula | C17H12ClNO4S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kim MJ, et al. Retrovirology. 2015 Nov 6;12:90.
2. Suppiah J, et al. Hepat Mon. 2014 Nov 30;14(12):e22565.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
