CliMB-325 | MHC‑I inducer | Probechem Biochemicals

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Chemical Structure : CliMB-325

CliMB-325 (Click MHC-I Booster-325, CliMB325)

Catalog No.: PC-25773Not For Human Use, Lab Use Only.

CliMB-325 is a small molecule modulator/ inducer of MHC‑I surface expression, induces MHC-I surface expression levels in CT26 cells with EC50 of 498 nM, also enhances T cell activation and exhibits lower toxicity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	386.20
Formula	C15H9Cl2N9
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-((2-amino-6-chloro-9H-purin-9-yl)methyl)-1H-1,2,3-triazol-1-yl)-5-chlorobenzonitrile

References

1. Newkirk SE, et al. J Med Chem. 2025 Nov 13;68(21):22301-22311.

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CliMB-325 (Click MHC-I Booster-325, CliMB325)

Biological Activity

Physicochemical Properties

References

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