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Chemical Structure : Clovibactin
Catalog No.: PC-21050Not For Human Use, Lab Use Only.
Clovibactin is a novel depsipeptide antibiotic, exhibits antibacterial activity against a broad range of Gram-positive pathogens (MIC, 1-2 ug/mL, ATCC 33591 MRSA), Clovibactin targets cell wall biosynthesis.
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Clovibactin is a novel depsipeptide antibiotic, exhibits antibacterial activity against a broad range of Gram-positive pathogens (MIC, 1-2 ug/mL, ATCC 33591 MRSA), Clovibactin targets cell wall biosynthesis.
Clovibactin exhibits antibacterial activity against a broad range of Gram-positive pathogens, including MRSA, daptomycin-resistant and vancomycin-intermediate-resistant S. aureus (VISA) strains, and difficult to treat vancomycin-resistant Enterococcus faecalis20 and E. faecium (vancomycin-resistant enterococci [VRE]).
Clovibactin is more effective in killing S. aureus compared with vancomycin, the first line of defense antibiotic.
Clovibactin does not show any cytotoxicity against mammalian NIH/3T3 and HepG2 cells at 100 μg/mL.
Clovibactin is efficacious in a mouse model of S. aureus infection.
Clovibactin uses an unusual hydrophobic interface to target immutable pyrophosphate.
| M.Wt | 903.09 | |
| Formula | C43H70N10O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shukla R, et al. Cell. 2023 Aug 16:S0092-8674(23)00853-X.
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