Clozapine N-oxide

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Chemical Structure : Clozapine N-oxide

CAS No.: 34233-69-7

Catalog No.: PC-45185Not For Human Use, Lab Use Only.

Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist, activates the DREADD receptor hM3Dq and hM4Di, a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor agonist with EC50 of 11 nM.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$198	In stock
100 mg	$328	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist, activates the DREADD receptor hM3Dq and hM4Di, a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor agonist with EC50 of 11 nM.

Physicochemical Properties

M.Wt	342.8227
Formula	C18H19ClN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-

References

1. Wess J, et al. Trends Pharmacol Sci. 2013 Jul;34(7):385-92.

2. Chang WH, et al. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):723-39.

3. Gomez JL, et al. Science. 2017 Aug 4;357(6350):503-507.

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