Compound 1105486

Chemical Structure : Compound 1105486

Catalog No.: PC-25464Not For Human Use, Lab Use Only.

Compound 1105486 is a selective small molecule inhibitor of β-1,4-galactosyltransferase 1 (B4GALT1), suppresses PANC-1 cell proliferation with an IC50 of 19.8 uM, exhibiting no significant cytotoxicity toward hTERT-HPNE normal pancreatic ductal epithelial cells up to 80 uM

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Biological Activity

Compound 1105486 is a selective small molecule inhibitor of β-1,4-galactosyltransferase 1 (B4GALT1), suppresses PANC-1 cell proliferation with an IC50 of 19.8 uM, exhibiting no significant cytotoxicity toward hTERT-HPNE normal pancreatic ductal epithelial cells up to 80 uM.

Physicochemical Properties

M.Wt	471.50
Formula	C23H22FN3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-cyano-6-oxo-4-(3,4,5-trimethoxyphenyl)-3,4,5,6-tetrahydropyridin-2-yl)thio)-N-(4-fluorophenyl)acetamide

References

1. Yunyun X, et al. Front Chem. 2025 Aug 11;13:1651402.

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