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Compound 11626252

Chemical Structure : Compound 11626252

CAS No.: 3010279-62-3

Compound 11626252

Catalog No.: PC-72403Not For Human Use, Lab Use Only.

Compound 11626252 is a potent, specific antitubercular agent against Mycobacterium tuberculosis (M. tb) with MIC of 0.02 ug/mL, targets cytochrome bc1 complex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Compound 11626252 is a potent, specific antitubercular agent against Mycobacterium tuberculosis (M. tb) with MIC of 0.02 ug/mL, targets cytochrome bc1 complex.
    Compound 11626252 demonstrated ex vivo activity in THP-1 macrophages infected with M.tb H37Rv with IC50 of 0.011 ug/mL.
    Compound 11626252 showed no activity against DS- and DR-members of the M. tb complex (MTBC), as well as against their close relative, M. marinum.
    The mutation in QcrA (L356V) is responsible for resistance to Compound 11626252.

    Physicochemical Properties

    M.Wt 237.296
    Formula C11H12FN3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(ethylthio)-8-fluoro-N-methylquinazolin-4-amine

    References

    1. Andréanne Lupien, et al. PLoS Pathog. 2020 Jan 23;16(1):e1008270.

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