Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Immunology/Inflammation-Immune Checkpoints-Compound 6809-0223
Compound 6809-0223

Chemical Structure : Compound 6809-0223

CAS No.: 669749-25-1

Add to Favorites

Compound 6809-0223 (VISTA antagonist)

Catalog No.: PC-38588Not For Human Use, Lab Use Only.

Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD).

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD).
    Compound 6809-0223 increases IL-2 secretion by CD4+ and CD8+ T cells, also increases murine CD4+ T cell proliferation.
    Compound 6809-0223 increases production of the IL-2, IL-4, IFN-γ and TNF-α cytokines in CD8+ T cells.

    Physicochemical Properties

    M.Wt 411.502
    Formula C18H17N7OS2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4,6-dimethylquinazolin-2-yl)amino)-6-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)pyrimidin-4(3H)-one

    References

    1. Ting-Ting Li, et al. BMC Immunol. 2021 Aug 11;22(1):55.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: