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Chemical Structure : Compound 6809-0223
Catalog No.: PC-38588Not For Human Use, Lab Use Only.
Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD).
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Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD).
Compound 6809-0223 increases IL-2 secretion by CD4+ and CD8+ T cells, also increases murine CD4+ T cell proliferation.
Compound 6809-0223 increases production of the IL-2, IL-4, IFN-γ and TNF-α cytokines in CD8+ T cells.
| M.Wt | 411.502 | |
| Formula | C18H17N7OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ting-Ting Li, et al. BMC Immunol. 2021 Aug 11;22(1):55.
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