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Compound 6809-0223

Chemical Structure : Compound 6809-0223

CAS No.: 669749-25-1

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Compound 6809-0223 (VISTA antagonist)

Catalog No.: PC-38588Not For Human Use, Lab Use Only.

Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD).
    Compound 6809-0223 increases IL-2 secretion by CD4+ and CD8+ T cells, also increases murine CD4+ T cell proliferation.
    Compound 6809-0223 increases production of the IL-2, IL-4, IFN-γ and TNF-α cytokines in CD8+ T cells.

    Physicochemical Properties

    M.Wt 411.502
    Formula C18H17N7OS2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4,6-dimethylquinazolin-2-yl)amino)-6-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)pyrimidin-4(3H)-one

    References

    1. Ting-Ting Li, et al. BMC Immunol. 2021 Aug 11;22(1):55.

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