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Chemical Structure : Compound 7004
Catalog No.: PC-35135Not For Human Use, Lab Use Only.
Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation.
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Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33-induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation.
Compound 7004 decreases the IRAK2-IRAK4 association, attenuates IL-33-induced and OVA-induced asthma mouse models in vivo.
Compound 7004 attenuates the proinflammatory effects in asthma-like models.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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