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Compound RP20

Chemical Structure : Compound RP20

CAS No.: 2910860-73-8

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Compound RP20

Catalog No.: PC-25227Not For Human Use, Lab Use Only.

Compound RP20 is a potent, selective RIPK2 inhibitor with IC50 of 13 nM, does not inhibit RIPK1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Compound RP20 is a potent, selective RIPK2 inhibitor with IC50 of 13 nM, does not inhibit RIPK1.
RP20 demonstrated minimal inhibition against DDR1, KDR, RET and PI3Kδ.
RP20 effectively inhibits RIPK2 activity in vivo, blocking downstream inflammatory signals and subsequently affecting the synthesis and release of the cytokine IL-6.
RP20 (20 mg/kg) has hepatoprotective effects on ALI models and exhibits liver-targeting properties.

Physicochemical Properties

M.Wt 465.57
Formula C23H20FN5OS2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(4-((6-fluorobenzo[d]thiazol-5-yl)amino)thieno[2,3-d]pyrimidin-6-yl)cyclohex-3-en-1-yl)cyclopropanecarboxamide

References

1. Chen Y, et al. Acta Pharm Sin B. 2025 Jul;15(7):3708-3724.

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