Concanamycin B | V-ATPase inhibitor | Probechem Biochemicals

Chemical Structure : Concanamycin B

Concanamycin B (MCH 210)

Catalog No.: PC-27522Not For Human Use, Lab Use Only.

Concanamycin B is a macrolide antibiotic and potent, specific vacuolar type H+-ATPase (V-ATPase) inhibitor with IC50 of 5 nM.

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Biological Activity

Concanamycin B is a macrolide antibiotic and potent, specific vacuolar type H+-ATPase (V-ATPase) inhibitor with IC50 of 5 nM.
Concanamycin B inhibits PTH-stimulated osteoclastic pit formation and suppresses the acidification of vacuolar organelles by V-ATPase in the osteoclasts.
Concanamycin B also inhibits PTH-stimulated 45Ca release from prelabelled chick embryonic calvariae.
Concanamycin B inhibits the expression of MHC class II molecules on Colo 205 cells, does not affect the expression of MHC class I and ICAM-1 molecules.
Concanamycin B suppresses the antigen presentation by MHC class II molecules.

Physicochemical Properties

M.Wt	852.06
Formula	C45H73NO14
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Oxacyclooctadeca-3,5,13,15-tetraen-2-one, 18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8,10-dihydroxy-3,17-dimethoxy-5,7,9,11,13-pentamethyl-, (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-

References

1. Woo JT, et al. Eur J Biochem. 1992 Jul 1;207(1):383-9.

2. Yilla M, et al. J Biol Chem. 1993 Sep 5;268(25):19092-100.

3. Fredericksen BL, et al. J Virol. 2002 Nov;76(22):11440-6.

4. Ito K, et al. J Antibiot (Tokyo). 1995 Jun;48(6):488-94.

Concanamycin B (MCH 210)

Biological Activity

Physicochemical Properties

References

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