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Conivaptan

Chemical Structure : Conivaptan

CAS No.: 210101-16-9

Conivaptan (YM-087;ZINC 12503187)

Catalog No.: PC-70166Not For Human Use, Lab Use Only.

Conivaptan (YM-087) is a potent, selective, nonpeptide vasopressin V1A and V2 receptor antagonist with Ki of 0.48 nM and 3.04 nM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Conivaptan (YM-087) is a potent, selective, nonpeptide vasopressin V1A and V2 receptor antagonist with Ki of 0.48 nM and 3.04 nM respectively.
Conivaptan (YM-087) has less potency for OT receptors and no effect on V1B receptor.
Conivaptan (YM-087) blocks AVP-induced cAMP production of cultured renal epithelium cells concentration dependently and has no agonistic activities.

Physicochemical Properties

M.Wt 498.583
Formula C32H26N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxamide

References

1. Tahara A, et al. J Pharmacol Exp Ther. 1997 Jul;282(1):301-8.

2. Tahara A, et al. Cardiovasc Res. 1998 Apr;38(1):198-205.

3. Nakayama S, et al. Neurocrit Care. 2016 Apr;24(2):273-82.

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