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Chemical Structure : Consomatin Fj1
Catalog No.: PC-22362Not For Human Use, Lab Use Only.
Consomatin Fj1 is a potent and selective SSTR 4 peptide agonist with EC50 of 6 nM.
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Consomatin Fj1 is a potent and selective somatostatin receptor 4 (SSTR4) peptide agonist with EC50 of 6 nM.
Consomatin Fj1 shows imited activity at SSTR1 (~30 % activation at 1 µM) and no activation of the SSTR2, 3, and 5.
Consomatin Fj1 is a mimetic of the endogenous hormone somatostatin and contains a minimized binding motif that provides stability and drives peptide selectivity.
Consomatin Fj1 induces G protein dissociation at the SSTR4.
Peripheral administration of synthetic consomatin Fj1 provided analgesia in mouse models of postoperative and neuropathic pain.
| M.Wt | 1165.44 | |
| Formula | C55H80N12O12S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Walden E Bjørn-Yoshimoto, et al. bioRxiv [Preprint]. 2024 Apr 30:2024.04.29.591104.
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