Chemical Structure : Consomatin Fj1
CAS No.:
2991332-82-0
Consomatin Fj1
(Pro-Val-Cys-D-Trp-Lys-Phe-Gly-Cys-Hyp-Leu)
Catalog No.: PC-22362Not For Human Use, Lab Use Only.
Consomatin Fj1 is a potent and selective SSTR 4 peptide agonist with EC50 of 6 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Consomatin Fj1 is a potent and selective somatostatin receptor 4 (SSTR4) peptide agonist with EC50 of 6 nM.
Consomatin Fj1 shows imited activity at SSTR1 (~30 % activation at 1 µM) and no activation of the SSTR2, 3, and 5.
Consomatin Fj1 is a mimetic of the endogenous hormone somatostatin and contains a minimized binding motif that provides stability and drives peptide selectivity.
Consomatin Fj1 induces G protein dissociation at the SSTR4.
Peripheral administration of synthetic consomatin Fj1 provided analgesia in mouse models of postoperative and neuropathic pain.
Physicochemical Properties
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M.Wt
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1165.44
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Formula
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C55H80N12O12S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((2S)-1-(L-prolyl-L-valyl-L-cysteinyl-D-tryptophyl-L-lysyl-L-phenylalanylglycyl-L-cysteinyl)-4-hydroxypyrrolidine-2-carbonyl)-L-leucine
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References
1. Walden E Bjørn-Yoshimoto, et al. bioRxiv [Preprint]. 2024 Apr 30:2024.04.29.591104.
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