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Chemical Structure : Conteltinib
CAS No.: 1384860-29-0
Catalog No.: PC-61370Not For Human Use, Lab Use Only.
CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo.
CT-707 (Conteltinib) effectively inhibits the activation of FAK induced by cabozantinib.
CT-707 (Conteltinib) displays potent activities in arresting cancer cell growth, promoting cell detachment, and decreasing wound healing, also exhibits potent anticancer activities in vivo, inhibits tumor growth and metastasis in T47D, Karpas299, and 4T1 xenograft models.
| M.Wt | 635.832 | |
| Formula | C32H45N9O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[(2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-(propan-2-yl)benzene-1-sulfonamide |
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1. Patent WO/2012/092880A1.
2. Wang DD, et al. Mol Cancer Ther. 2016 Dec;15(12):2916-2925.
3. Cui C, et al. J Pharm Biomed Anal. 2018 Jan 31;153:1-8.
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