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Conteltinib

Chemical Structure : Conteltinib

CAS No.: 1384860-29-0

Conteltinib (CT-707, CT707)

Catalog No.: PC-61370Not For Human Use, Lab Use Only.

CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo.

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Biological Activity

CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo.
CT-707 (Conteltinib) effectively inhibits the activation of FAK induced by cabozantinib.
CT-707 (Conteltinib) displays potent activities in arresting cancer cell growth, promoting cell detachment, and decreasing wound healing, also exhibits potent anticancer activities in vivo, inhibits tumor growth and metastasis in T47D, Karpas299, and 4T1 xenograft models.

Physicochemical Properties

M.Wt 635.832
Formula C32H45N9O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[(2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-(propan-2-yl)benzene-1-sulfonamide

References

1. Patent WO/2012/092880A1.

2. Wang DD, et al. Mol Cancer Ther. 2016 Dec;15(12):2916-2925.

3. Cui C, et al. J Pharm Biomed Anal. 2018 Jan 31;153:1-8.

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