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Chemical Structure : Contilisant
Catalog No.: PC-35407Not For Human Use, Lab Use Only.
Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM.
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Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM; hBuChE IC50=1.69 µM; hMAO A IC50=0.145 µM; hMAO B IC50=0.078 µM; hH3R Ki =10.8 nM).
Contilisant also is an affine and selective S1R agonist (Ki=65.2 nM).
Contilisant significantly restores the cognitive deficit induced by Aβ1-42 in the radial maze assay in an in vivo Alzheimer's disease model.
Contilisant significantly improves lipopolysaccharide-induced cognitive deficits.
| M.Wt | 353.51 | |
| Formula | C22H31N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bautista-Aguilera ÓM, et al. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12765-12769.
2. Bautista-Aguilera ÓM, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00848.
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