Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Contilisant
Catalog No.: PC-35407Not For Human Use, Lab Use Only.
Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM; hBuChE IC50=1.69 µM; hMAO A IC50=0.145 µM; hMAO B IC50=0.078 µM; hH3R Ki =10.8 nM); Contilisant also is an affine and selective S1R agonist (Ki=65.2 nM); significantly restores the cognitive deficit induced by Aβ1-42 in the radial maze assay in an in vivo Alzheimer's disease model; significantly improves lipopolysaccharide-induced cognitive deficits.
| M.Wt | 353.51 | |
| Formula | C22H31N3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Bautista-Aguilera ÓM, et al. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12765-12769.
2. Bautista-Aguilera ÓM, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00848.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
