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Coptisine chloride

Chemical Structure : Coptisine chloride

CAS No.: 6020-18-4

Coptisine chloride

Catalog No.: PC-22274Not For Human Use, Lab Use Only.

Coptisine chloride is an alkaloid from Chinese goldthread, and is an efficient uncompetitive indoleamine 2,3-Dioxygenase (IDO) inhibitor, also is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6 μg/mL, also is a novel METTL3 inhibitor and performs therapeutic effect on periodontitis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Coptisine chloride is an alkaloid from Chinese goldthread, and is an efficient uncompetitive indoleamine 2,3-Dioxygenase (IDO) inhibitor, also is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6 μg/mL, also is a novel METTL3 inhibitor and performs therapeutic effect on periodontitis.

Physicochemical Properties

M.Wt 355.77
Formula C19H14ClNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium chloride

References

1. Xinyi Zhou, et al. Adv Sci (Weinh). 2024 May 2:e2308786.

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