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Chemical Structure : Cotadutide acetate
CAS No.: 1903768-17-1
Catalog No.: PC-72602Not For Human Use, Lab Use Only.
Cotadutide acetate (MEDI-0382, MEDI0382) is a potent dual GLP-1/glucagon receptor peptide agonist with EC50 values of 6.9 pM and 10.2 pM, respectively.
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Cotadutide acetate (MEDI-0382, MEDI0382) is a potent dual GLP-1/glucagon receptor peptide agonist with EC50 values of 6.9 pM and 10.2 pM, respectively.
Cotadutide (MEDI-0382, MEDI0382) stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively ), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively).
Cotadutide (MEDI-0382, MEDI0382) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β‐cell line and increases glucose output in rat hepatocytes.
Cotadutide (MEDI-0382, MEDI0382) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes.
Cotadutide (MEDI-0382, MEDI0382) (10- 30 nmol/kg, s.c.) suppresses food intake and reduces body weight in DIO mice, reduces hepatic fibrosis and inflammation in in ob/ob AMLN NASH mice.
| M.Wt | 3788.14 | |
| Formula | C169H256N42O57 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,4R)-1-{[3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol1-yl]acetyl}-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine2-carboxamide |
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1. Henderson SJ, et al. Diabetes Obes Metab. 2016 Dec;18(12):1176-1190.
2. Ambery PD, et al. Br J Clin Pharmacol. 2018 Oct;84(10):2325-2335.
3. Ambery P, et al. Lancet. 2018 Jun 30;391(10140):2607-2618.
4. Boland ML, et al. Nat Metab. 2020 May;2(5):413-431.
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