Cotadutide acetate (MEDI-0382, MEDI0382) is a potent dual GLP-1/glucagon receptor peptide agonist with EC50 values of 6.9 pM and 10.2 pM, respectively.
Cotadutide (MEDI-0382, MEDI0382) stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively ), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively).
Cotadutide (MEDI-0382, MEDI0382) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β‐cell line and increases glucose output in rat hepatocytes.
Cotadutide (MEDI-0382, MEDI0382) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes.
Cotadutide (MEDI-0382, MEDI0382) (10- 30 nmol/kg, s.c.) suppresses food intake and reduces body weight in DIO mice, reduces hepatic fibrosis and inflammation in in ob/ob AMLN NASH mice.