Cowanin |CAS:21044-85-9 Probechem Biochemicals

Chemical Structure : Cowanin

Cowanin (NSC 752810)

Catalog No.: PC-63246Not For Human Use, Lab Use Only.

Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM.

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Biological Activity

Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM; shows high efficient cytotoxicity against human leukemic cancer cells HPB-ALL (IC50=7.5 uM) than that of DAPT, decreases the protein levels of HES1 and HES5 in assay cells; accelerates nicastrin degradation, which is one of the components of the γ-secretase complex; also inhibits cell proliferation and induces apoptosis of LoVo cells via the MAPK and Akt signaling pathways.

Physicochemical Properties

M.Wt	478.585
Formula	C29H34O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(2E)-3,7-dimethylocta-2,6-dienyl]-3,6,8-trihydroxy-2-methoxy-7-(3-methylbut-2-enyl)xanthen-9-one

References

1. Arai MA, et al. Sci Rep. 2018 Mar 29;8(1):5376.

2. Chowchaikong N, et al. Int J Oncol. 2018 Apr 3. doi: 10.3892/ijo.2018.4353.

Cowanin (NSC 752810)

Biological Activity

Physicochemical Properties

References

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