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Chemical Structure : Crebinostat
CAS No.: 1092061-61-4
Catalog No.: PC-62704Not For Human Use, Lab Use Only.
Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9.
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|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9.
Crebinostat potently induces acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 in cultured mouse primary neurons.
Crebinostat upregulates Bdnf and Grn, and downregulates Mapt (tau) gene expression-genes; brain penetrant.
| M.Wt | 353.422 | |
| Formula | C20H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Heptanoic acid,7-(hydroxyamino)-7-oxo-,2-([1,1'-biphenyl]-4-ylmethylene)hydrazide |
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1. Fass DM, et al. Neuropharmacology. 2013 Jan;64:81-96.
2. Ghosh B, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-71.
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