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Crisaborole

Chemical Structure : Crisaborole

CAS No.: 906673-24-3

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Crisaborole (AN-2728, AN2728)

Catalog No.: PC-42760Not For Human Use, Lab Use Only.

Crisaborole (AN-2728) is a potent PDE4 inhibitor with IC50 of 0.49 uM.

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50 mg $58 In stock
100 mg $88 In stock
500 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Crisaborole (AN-2728) is a potent PDE4 inhibitor with IC50 of 0.49 uM.
Crisaborole (AN-2728) also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1.
Crisaborole (AN-2728) suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.

Physicochemical Properties

M.Wt 251.0451
Formula C14H10BNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

Benzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-

References

1. Akama T, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.

2. Nazarian R, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.

3. Freund YR, et al. FEBS Lett. 2012 Sep 21;586(19):3410-4.

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