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Chemical Structure : Cucurbitacin I
CAS No.: 2222-07-3
Catalog No.: PC-60456Not For Human Use, Lab Use Only.
Cucurbitacin I (JSI-124) is a triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $198 | In stock | |
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Cucurbitacin I (JSI-124) is a triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM.
Cucurbitacin I shows high selectivity for JAK/STAT3 and does not inhibit other oncogenic and tumor survival pathways such as Akt, ERK1/2, JNK.
Cucurbitacin I inhibits STAT3 DNA binding and STAT3-mediated gene transcription, also decreases the levels of tyrosine-phosphorylated JAK but not Src.
Cucurbitacin I also inhibits Rac1 activation in breast cancer cells.
| M.Wt | 514.7 | |
| Formula | C30H42O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(10α)-2,16α,20,25-tetrahydroxy-9β-methyl-19-norlanosta-1,5,23E-triene-3,11,22-trione |
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1. Blaskovich MA, et al. Cancer Res. 2003 Mar 15;63(6):1270-9.
2. Witkowski A, et al. Biochem Pharmacol. 1984 Apr 1;33(7):995-1004.
3. Nefedova Y, et al. Cancer Res. 2005 Oct 15;65(20):9525-35.
4. Lopez-Haber C, et al. Mol Pharmacol. 2013 May;83(5):1141-54.
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