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Cyclo(RGDfK)

Chemical Structure : Cyclo(RGDfK)

CAS No.: 161552-03-0

Cyclo(RGDfK) (Cyclo (RGDfK) peptide, Cyclic RGDfK peptide)

Catalog No.: PC-47465Not For Human Use, Lab Use Only.

Cyclo(RGDfK) is a RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cyclo(RGDfK) is a RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM.
Cyclo(RGDfK) shows strong inhibitory effect on the proliferation of T-24 cells.
Cyclo(RGDfK) induces less tumor progression, less tumor metabolic activity, fewer intratumoral vessels in mice model.

Physicochemical Properties

M.Wt 603.6705
Formula C27H41N9O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥150 mg/mL

Chemical Name/SMILES

Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl)

References

1. Sancey L, et al. Mol Ther. 2009, 17(5), 837-843.

2. Zhou D, et al. J Control Release. 2013, 169(3), 204-210.

3. Vilchis-Juarez A, et al. J Biomed Nanotechnol. 2014 Mar;10(3):393-404.

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