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Cyclo(RGDyK)

Chemical Structure : Cyclo(RGDyK)

CAS No.: 250612-42-1

Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys)

Catalog No.: PC-70068Not For Human Use, Lab Use Only.

Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with IC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Cyclo(RGDyK) is a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including αvβ3.

Physicochemical Properties

M.Wt 847.72
Formula C31H43F6N9O12
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl), bis(trifluoroacetate) (salt) (9CI)

References

1. Haubner R, et al. J Nucl Med. 2001 Feb;42(2):326-36.

2. Chen Y, et al. PLoS One. 2016 Mar 1;11(3):e0149952.

3. Guo L, et al. J Nanosci Nanotechnol. 2014 Jul;14(7):4858-64.

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