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Chemical Structure : Cyclothiazide
Catalog No.: PC-61706Not For Human Use, Lab Use Only.
Cyclothiazide (Doburil) is a positive allosteric modulator of the AMPA and kainate receptors that potentiates AMPA-mediated glutamate currents.
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Cyclothiazide (Doburil) is a positive allosteric modulator of the AMPA and kainate receptors that potentiates AMPA-mediated glutamate currents; also acts as a GABAA receptor negative allosteric modulator, potently inhibiting GABAA-mediated currents; induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo.
| M.Wt | 389.88 | |
| Formula | C14H16ClN3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamada KA, et al. J Neurosci. 1993 Sep;13(9):3904-15.
2. Deng L, et al. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13025-9.
3. Qi J, et al. J Physiol. 2006 Mar 15;571(Pt 3):605-18.
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