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Cytochalasin A

Chemical Structure : Cytochalasin A

CAS No.: 14110-64-6

Cytochalasin A

Catalog No.: PC-28244Not For Human Use, Lab Use Only.

Cytochalasin A is a cell-permeable fungal toxin and oxidized derivative of cytochalasin B, inhibits actin polymerization of brain tubulin and muscle actin, also inhibits HIV-1 protease with IC50 of 3 uM, inhibits growth and glucose transport in Saccharomyces.

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Biological Activity

Cytochalasin A is a cell-permeable fungal toxin and oxidized derivative of cytochalasin B, inhibits actin polymerization of brain tubulin and muscle actin, also inhibits HIV-1 protease with IC50 of 3 uM, inhibits growth and glucose transport in Saccharomyces.

Physicochemical Properties

M.Wt 477.59
Formula C29H35NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3S,3aS,4S,6S,6aS,7E,10R,15Z,18aS)-3-benzyl-6-hydroxy-4,10-dimethyl-5-methylene-2,3,3a,4,5,6,6a,9,10,11,12,13-dodecahydro-1H-[1]oxacyclotetradecino[2,3-d]isoindole-1,14,17-trione

References

1. Manavathu EK, et al. Biochem Biophys Res Commun. 1976 Jul 12;71(1):280-5.

2. Himes RH, et al. Biochem Biophys Res Commun. 1976 Feb 23;68(4):1362-70.

3. Cunningham D, et al. J Bacteriol. 1979 Feb;137(2):925-32.

4. Jones LA, et al. Eukaryot Cell. 2010 Oct;9(10):1455-65.

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