Catalog No.: PC-38029Not For Human Use, Lab Use Only.
D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding with Kd of 1.4 uM, is commonly used to inhibit NMDA-dependent synaptic plasticity.
D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding with Kd of 1.4 uM, is commonly used to inhibit NMDA-dependent synaptic plasticity.
D-AP5 reduces NMDA-induced depolarization of cortical neurons in vitro.
Following spinal injection, D-AP5 results in rapid reduction of NMDA-response but no effect on spontaneously active neurons.
Physicochemical Properties
M.Wt
197.127
Formula
C5H12NO5P
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(R)-2-Amino-5-phosphonopentanoic acid
References
1. Davies J, et al. Brain Res. 1986 Sep 10;382(1):169-73.
2. Javitt DC, et al. Neurosci Lett. 1987 Jul 22;78(2):193-8.
3. Manallack DT, et al. Neuroscience. 1989;30(1):87-94.
4. Coleman PA, et al. J Neurosci. 1988 Dec;8(12):4728-33.
