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D-Cl-amidine hydrochloride

Chemical Structure : D-Cl-amidine hydrochloride

CAS No.: 2985338-61-0

D-Cl-amidine hydrochloride

Catalog No.: PC-27308Not For Human Use, Lab Use Only.

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor with kinact/KI of 1220 M-1 min-1, displays 50-, 204- and 10-fold selectivity over PAD2, PAD3 and PAD4 respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor with kinact/KI of 1220 M-1 min-1, displays 50-, 204- and 10-fold selectivity over PAD2, PAD3 and PAD4 respectively.

Physicochemical Properties

M.Wt 347.24
Formula C14H20Cl2N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-(1-amino-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)benzamide hydrochloride

References

1. Bicker KL, et al. ACS Med. Chem. Lett 3 (12) (2012) 1081–1085.

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