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Chemical Structure : D-G23
Catalog No.: PC-61929Not For Human Use, Lab Use Only.
D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro.
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D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro.
D-G23 suppresses growth of BRCA1- and BRCA2-deficient cells (at >10 uM concentration).
| M.Wt | 354.41 | |
| Formula | C19H22N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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