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D-G23

Chemical Structure : D-G23

CAS No.: 1225141-73-0

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D-G23 (RAD52 inhibitor)

Catalog No.: PC-61929Not For Human Use, Lab Use Only.

D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro.
    D-G23 suppresses growth of BRCA1- and BRCA2-deficient cells (at >10 uM concentration).

    Physicochemical Properties

    M.Wt 354.41
    Formula C19H22N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((2-((2,5-dimethoxyphenyl)amino)quinazolin-4-yl)amino)propan-1-ol

    References

    1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99.

    2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

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