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Chemical Structure : D-I03
CAS No.: 688342-78-1
Catalog No.: PC-61928Not For Human Use, Lab Use Only.
D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro。
D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells (at 2.5 uM concentration) and inhibits RAD52-mediated SSA in human U2OS cells。
D-I03 selective toward SSA over homologous recombination (HR).
| M.Wt | 428.643 | |
| Formula | C23H36N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2-(diethylamino)ethyl)-3-(2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl)thiourea |
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1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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