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D159153

Chemical Structure : D159153

CAS No.: 2734371-28-7

D159153 (D-159153;D 159153)

Catalog No.: PC-35906Not For Human Use, Lab Use Only.

D159153 (D-159153) is a novel potent, allosteric inhibitor of PDE4 with cellular IC50 of 28.5 and 6.6 nM for PDE4B1 and PDE4D3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    D159153 (D-159153) is a novel potent, allosteric inhibitor of PDE4 with cellular IC50 of 28.5 and 6.6 nM for PDE4B1 and PDE4D3, respectively.

    Physicochemical Properties

    M.Wt 397.45
    Formula C22H24FN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(4-(4-ethyl-2-fluoro-3-((2E,4E)-5-nitrohexa-2,4-dien-3-yl)benzyl)phenyl)urea

    References

    1. Wunder F, et al. Mol Pharm. 2013 Oct 7;10(10):3697-705.

    2. Zhang C, et al. Neuropsychopharmacology. 2018 Oct;43(11):2299-2309.

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