D211 |CAS:1971075-99-6 Probechem Biochemicals

Chemical Structure : D211

D211 ((S,S)-D211;D-211)

Catalog No.: PC-60140Not For Human Use, Lab Use Only.

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs).

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Biological Activity

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.

Physicochemical Properties

M.Wt	656.739
Formula	C39H36N4O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(6aS,6a'S)-3,3'-(propane-1,3-diylbis(oxy))bis(2-methoxy-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinolin-14(6aH)-one)

References

1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436

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D211 ((S,S)-D211;D-211)

Biological Activity

Physicochemical Properties

References

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