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Chemical Structure : D4476
CAS No.: 301836-43-1
Catalog No.: PC-42523Not For Human Use, Lab Use Only.
D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
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|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
D4476 slightly weaker for ALK5 inhibition (IC50=0.5 uM); weak activity for p38α MAPK and no activity for PKB, SGK.
D4476 specifically inhibits the phosphorylation of endogenous FOXO1a on Ser322 and Ser325.
D4476 more potent and specific than IC261 or CKI-7.
| M.Wt | 398.414 | |
| Formula | C23H18N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]- |
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1. Rena G, et al. EMBO Rep. 2004 Jan;5(1):60-5.
2. Bryja V, et al. Cell Signal. 2007 Mar;19(3):610-6.
3. Huart AS, et al. J Biol Chem. 2009 Nov 20;284(47):32384-94.
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