D609 is a competitive inhibitor of PC-PLC with Ki of 6.4 uM, also is a small molecule of sphingomyelin synthase (SMS1 and SMS2).
D609 does not affect bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D; has antioxidant, antiviral, and anti-tumor activities.
D609 also shows anti-inflammatory actions, blocking the induction of nitric oxide synthase by LPS in phagocytes (IC50=20 ug/ml).
Physicochemical Properties
M.Wt
266.4645
Formula
C11H15KOS2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Carbonodithioic acid, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, potassium salt (1:1)
References
1. Amtmann E. Drugs Exp Clin Res. 1996;22(6):287-94.
2. Adibhatla RM, et al. Neurochem Res. 2012 Apr;37(4):671-9.
3. Tschaikowsky K, et al. Br J Pharmacol. 1994 Nov;113(3):664-8.
