D6808 | c-MET inhibitor | Probechem Biochemicals

Chemical Structure : D6808

D6808 (D-6808)

Catalog No.: PC-49451Not For Human Use, Lab Use Only.

D6808 is a highly selective and potent macrocyclic c-Met inhibitor with IC50 of 2.9 nM.

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Biological Activity

D6808 is a highly selective and potent macrocyclic c-Met inhibitor with IC50 of 2.9 nM.
D6808 potently inhibited c-Met kinase and MET-amplified Hs746T gastric cancer cells with IC50 values of 2.9 and 0.7 nM, respectively.
D6808 also strongly suppressed Ba/F3-Tpr-Met cells harboring resistance-relevant mutations (F1200L/M1250T/H1094Y/F1200I/L1195V) with IC50 values of 4.2, 3.2, 1.0, 39.0, and 33.4 nM, respectively.
D6808 exhibited extraordinary target specificity in a Kinome profiling against 373 wild-type kinases.

Physicochemical Properties

M.Wt	558.565
Formula	C30H25F3N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(14Z,52E)-63-(trifluoromethyl)-51,56-dihydro-11H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-56,7-dione

References

1. Wang C, et al. J Med Chem. 2022 Nov 10. doi: 10.1021/acs.jmedchem.2c00981.

D6808 (D-6808)

Biological Activity

Physicochemical Properties

References

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