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Chemical Structure : D6808
Catalog No.: PC-49451Not For Human Use, Lab Use Only.
D6808 is a highly selective and potent macrocyclic c-Met inhibitor with IC50 of 2.9 nM.
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D6808 is a highly selective and potent macrocyclic c-Met inhibitor with IC50 of 2.9 nM.
D6808 potently inhibited c-Met kinase and MET-amplified Hs746T gastric cancer cells with IC50 values of 2.9 and 0.7 nM, respectively.
D6808 also strongly suppressed Ba/F3-Tpr-Met cells harboring resistance-relevant mutations (F1200L/M1250T/H1094Y/F1200I/L1195V) with IC50 values of 4.2, 3.2, 1.0, 39.0, and 33.4 nM, respectively.
D6808 exhibited extraordinary target specificity in a Kinome profiling against 373 wild-type kinases.
| M.Wt | 558.565 | |
| Formula | C30H25F3N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang C, et al. J Med Chem. 2022 Nov 10. doi: 10.1021/acs.jmedchem.2c00981.
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