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Chemical Structure : D715-2441
Catalog No.: PC-35605Not For Human Use, Lab Use Only.
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM.
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D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM; does not inhibit both viral entry and release, disrupts early influenza A virus replication, reduces vRNP activity and affects PB2 protein localization; shows binding affinity to influenza PB2cap protein with Kd of 0.118 uM; demonstrates a remarkable synergistic antiviral effect (FICI value of 0.40) combined with zanamivir.
| M.Wt | 228.203 | |
| Formula | C13H8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu T, et al. Mol Pharm. 2018 Aug 23. doi: 10.1021/acs.molpharmaceut.8b00531.
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