Chemical Structure : D715-2441
CAS No.:
54245-10-2
D715-2441
(D 715-2441)
Catalog No.: PC-35605Not For Human Use, Lab Use Only.
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM; does not inhibit both viral entry and release, disrupts early influenza A virus replication, reduces vRNP activity and affects PB2 protein localization; shows binding affinity to influenza PB2cap protein with Kd of 0.118 uM; demonstrates a remarkable synergistic antiviral effect (FICI value of 0.40) combined with zanamivir.
Physicochemical Properties
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M.Wt
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228.203
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Formula
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C13H8O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1,3-dihydroxy-6H-benzo[c]chromen-6-one
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References
1. Liu T, et al. Mol Pharm. 2018 Aug 23. doi: 10.1021/acs.molpharmaceut.8b00531.
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