Catalog No.: PC-35605Not For Human Use, Lab Use Only.
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM.
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM.
D715-2441 does not inhibit both viral entry and release, disrupts early influenza A virus replication, reduces vRNP activity and affects PB2 protein localization.
D715-2441 shows binding affinity to influenza PB2cap protein with Kd of 0.118 uM.
D715-2441 demonstrates a remarkable synergistic antiviral effect (FICI value of 0.40) combined with zanamivir.
Physicochemical Properties
M.Wt
228.203
Formula
C13H8O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,3-dihydroxy-6H-benzo[c]chromen-6-one
References
1. Liu T, et al. Mol Pharm. 2018 Aug 23. doi: 10.1021/acs.molpharmaceut.8b00531.
