DA-023 | EAAT2 PAM | Probechem Biochemicals

Chemical Structure : DA-023

DA-023 (DA023)

Catalog No.: PC-28284Not For Human Use, Lab Use Only.

DA-023 is a potent, selective positive allosteric modulator (PAM) of excitatory amino acid transporter 2 (EAAT2) with EC50 of 1.0 nM, is inactive against EAAT1 and EAAT3.

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Biological Activity

DA-023 is a potent, selective positive allosteric modulator (PAM) of excitatory amino acid transporter 2 (EAAT2) with EC50 of 1.0 nM, is inactive against EAAT1 and EAAT3.

Physicochemical Properties

M.Wt	363.46
Formula	C20H25N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-4-((1-phenethyl-1H-tetrazol-5-yl)(pyridin-3-yl)methyl)piperazine

References

1. Fontana ACK, et al. J Med Chem. 2024 Apr 25;67(8):6119-6143.

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DA-023 (DA023)

Biological Activity

Physicochemical Properties

References

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