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DAA-1106

Chemical Structure : DAA-1106

CAS No.: 220551-92-8

DAA-1106 (DAA1106, DAA 1106)

Catalog No.: PC-45756Not For Human Use, Lab Use Only.

DAA-1106 is a potent, selective agonist of PBR/TSPO that inhibits [3H]PK 11195 binding to crude mitochondrial preparations of rat whole brain with IC50 of 0.92 nM.

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Biological Activity

DAA-1106 is a potent, selective agonist of PBR/TSPO that inhibits [3H]PK 11195 binding to crude mitochondrial preparations of rat whole brain with IC50 of 0.92 nM.
DAA-1106 significantly increases sleeping time in hexobarbital-induced anesthesia.
DAA-1106 has anxiolytic effects with no affect for spontaneous locomotor activity in mice; orally active.

Physicochemical Properties

M.Wt 395.4235
Formula C23H22FNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

Acetamide, N-[(2,5-dimethoxyphenyl)methyl]-N-(5-fluoro-2-phenoxyphenyl)-

References

1. Okuyama S, et al. Life Sci. 1999;64(16):1455-64.

2. Chaki S, et al. Eur J Pharmacol. 1999 Apr 29;371(2-3):197-204.

3. Okubo T, et al. Bioorg Med Chem. 2004 Jan 15;12(2):423-38.

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