DAN 004 |CAS: 2251049-11-1 Probechem Biochemicals

Chemical Structure : DAN004

DAN004 (DAN 004; DAN-004)

Catalog No.: PC-60941Not For Human Use, Lab Use Only.

DAN 004 is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.

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Biological Activity

DAN 004 is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.
DAN 004 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.

Physicochemical Properties

M.Wt	494.433
Formula	C26H28BrN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-((3-aminopropyl)(4-bromobenzyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide

References

1. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.

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DAN004 (DAN 004; DAN-004)

Biological Activity

Physicochemical Properties

References

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