Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DAPH-1
CAS No.: 145915-58-8
Catalog No.: PC-62186Not For Human Use, Lab Use Only.
DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture.
DAPH-1 inhibits prion nucleation by preventing both Head-to-Head and Tail-to-Tail intermolecular interactions.
DAPH-1 also is a potent and selective inhibitor of EGFR kinase with IC50 of 1 uM, selectively inhibits both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction.
| M.Wt | 329.359 | |
| Formula | C20H15N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione |
|
1. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.
2. Roberts BE, et al. Nat Chem Biol. 2009 Dec;5(12):936-46.
3. Buchdunger E, et al. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2334-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
