Catalog No.: PC-62186Not For Human Use, Lab Use Only.
DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture.
DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture.
DAPH-1 inhibits prion nucleation by preventing both Head-to-Head and Tail-to-Tail intermolecular interactions.
DAPH-1 also is a potent and selective inhibitor of EGFR kinase with IC50 of 1 uM, selectively inhibits both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction.
Physicochemical Properties
M.Wt
329.359
Formula
C20H15N3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
References
1. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.
2. Roberts BE, et al. Nat Chem Biol. 2009 Dec;5(12):936-46.
3. Buchdunger E, et al. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2334-8.
