DAPH-12 |CAS:145915-63-5 Probechem Biochemicals

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Chemical Structure : DAPH-12

DAPH-12 (DAPH12)

Catalog No.: PC-62187Not For Human Use, Lab Use Only.

DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
Combinations of DAPH-12 and EGCG more effectively inhibits spontaneous and seeds NM fibrillization, and more effectively eliminates NM4 and NM25 than either small molecule alone.

Physicochemical Properties

M.Wt	389.411
Formula	C22H19N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5,6-Bis[(4-methoxyphenyl)amino]-1H-isoindole-1,3(2H)-dione

References

1. Roberts BE, et al. Nat Chem Biol. 2009 Dec;5(12):936-46.

2. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.

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DAPH-12 (DAPH12)

Biological Activity

Physicochemical Properties

References

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