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Chemical Structure : DAPH-12
Catalog No.: PC-62187Not For Human Use, Lab Use Only.
DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
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DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
Combinations of DAPH-12 and EGCG more effectively inhibits spontaneous and seeds NM fibrillization, and more effectively eliminates NM4 and NM25 than either small molecule alone.
| M.Wt | 389.411 | |
| Formula | C22H19N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Roberts BE, et al. Nat Chem Biol. 2009 Dec;5(12):936-46.
2. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.
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