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Chemical Structure : DAS-5-oCRBN
Catalog No.: PC-21652Not For Human Use, Lab Use Only.
DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl.
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DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl.
Degradation requires binding to the ATP-site of c-Src, and is mediated by ubiquitination and proteasomal degradation of c-Src.
| M.Wt | 826.33 | |
| Formula | C39H40ClN11O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mao W, et al. ACS Chem Biol. 2023 Dec 19. doi: 10.1021/acschembio.3c00548.
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