DAS-5-oCRBN

Chemical Structure : DAS-5-oCRBN

Catalog No.: PC-21652Not For Human Use, Lab Use Only.

DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl.

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Biological Activity

DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl.
Degradation requires binding to the ATP-site of c-Src, and is mediated by ubiquitination and proteasomal degradation of c-Src.

Physicochemical Properties

M.Wt	826.33
Formula	C39H40ClN11O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)-2-oxoethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

References

1. Mao W, et al. ACS Chem Biol. 2023 Dec 19. doi: 10.1021/acschembio.3c00548.

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DAS-5-oCRBN

Biological Activity

Physicochemical Properties

References

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