Catalog No.: PC-26517Not For Human Use, Lab Use Only.
DB008 is a selective, covalent PARP16 inhibitor with IC50 of 0.275 uM, covalently reacts with a non-conserved cysteine (Cys169, human numbering) in the NAD+ binding pocket of PARP16.
DB008 is a selective, covalent PARP16 inhibitor with IC50 of 0.275 uM, covalently reacts with a non-conserved cysteine (Cys169, human numbering) in the NAD+ binding pocket of PARP16.
DB008 shows excellent selectivity profile among the MARylating PARPs, with one of the prominent off-targets as PARP2 (IC50=139 nM).
DB008 does not inhibit PARP1/2 in a covalent manner.
DB008 covalently modifies Cys169 of PARP16 and exhibits excellent proteome-wide selectivity in the irreversible binding mode.
DB008 stabilizes PARP16 levels during nutrient starvation.
