Catalog No.: PC-35797Not For Human Use, Lab Use Only.
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.
DB550 abrogates the binding of PLCγ1 to CD95 in cells exposed to s-CD95L, inhibits the CD95-mediated Ca2+ response in a similar manner in Th17 cells to minCID and preventes Th17 trafficking across endothelial cells, does not affect the CD95-mediated apoptotic signaling pathway.
DB550 abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 68 nM, alleviates clinical symptoms in lupus-prone mice.
