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Chemical Structure : DB550
Catalog No.: PC-35797Not For Human Use, Lab Use Only.
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.
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DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.
DB550 abrogates the binding of PLCγ1 to CD95 in cells exposed to s-CD95L, inhibits the CD95-mediated Ca2+ response in a similar manner in Th17 cells to minCID and preventes Th17 trafficking across endothelial cells, does not affect the CD95-mediated apoptotic signaling pathway.
DB550 abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 68 nM, alleviates clinical symptoms in lupus-prone mice.
| M.Wt | 1011.307 | |
| Formula | C43H82N18O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Poissonnier A, et al. Nat Chem Biol. 2018 Dec;14(12):1079-1089.
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