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DBIBB

Chemical Structure : DBIBB

CAS No.: 1569309-92-7

DBIBB

Catalog No.: PC-60889Not For Human Use, Lab Use Only.

DBIBB is a potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DBIBB is a potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors.
DBIBB displays 33-fold increased potency over GRI977143.
DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis.
DBIBB enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice.

Physicochemical Properties

M.Wt 452.5
Formula C23H20N2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid

References

1. Patil R, et al. Chem Biol. 2015 Feb 19;22(2):206-16.

2. Knowlden SA, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):402-9.

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