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Chemical Structure : DC-ATG4in
Catalog No.: PC-20716Not For Human Use, Lab Use Only.
DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.
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DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.
DC-ATG4in blocked autophagy induced by Sorafenib in Hepatocellular Carcinoma (HCC) cells.
Combination of DC-ATG4in with Sorafenib synergized the cancer cell killing effect and proliferation inhibition activities on HCC cells.
| M.Wt | 418.52 | |
| Formula | C23H22N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yanqiu Xie, et al. Bioorg Med Chem. 2023 Apr 15;84:117262.
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