DC-ATG4in

Chemical Structure : DC-ATG4in

Catalog No.: PC-20716Not For Human Use, Lab Use Only.

DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.

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Biological Activity

DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.
DC-ATG4in blocked autophagy induced by Sorafenib in Hepatocellular Carcinoma (HCC) cells.
Combination of DC-ATG4in with Sorafenib synergized the cancer cell killing effect and proliferation inhibition activities on HCC cells.

Physicochemical Properties

M.Wt	418.52
Formula	C23H22N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	S=C(N1CCCCCC1)NC2=CC=C3N=C(C4=CC=CO4)C(C5=CC=CO5)=NC3=C2

References

1. Yanqiu Xie, et al. Bioorg Med Chem. 2023 Apr 15;84:117262.

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DC-ATG4in

Biological Activity

Physicochemical Properties

References

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